PREECLAMPSIA: ENFOQUE Y PERSPECTIVA

  • Peter Stain Vargas Manrique Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia http://orcid.org/0000-0002-9855-9739
  • Jonathan Alexander Siabato Barrios Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia.
  • Juan Sebastián Castro Guerrero Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia.
  • Carlos Ernesto Morales Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia.
Palabras clave: Pre eclampsia, Embarazo, Gestación, Riesgo

Resumen

La preeclampsia es una alteración hipertensiva asociada a la gestación que se presenta frecuentemente y se asocia, principalmente en países subdesarrollados, con repercusiones materno – fetales como aumento de la morbimortalidad, parto pretérmino y restricción del crecimiento intrauterino. Se cree que su aparición se debe a anormalidades en la placentación junto a una respuesta inmune inadecuada, cambios moleculares y factores de crecimiento, junto a restos placentarios que en el sistema circulatorio materno desatan una respuesta inflamatoria traducida en hipertensión arterial materna. Dentro de las principales moléculas implicadas destacan el factor de crecimiento transformante derivado de las vesículas seminales β1, el papel de las células Natural Killer y citoquinas proinflamatorias y sus productos. El objetivo de esta revisión es el de conocer algunos factores moleculares y principios fisiopatológicos implicados en el inicio y progresión de la preeclampsia, con el fin de tener información útil para realizar diagnósticos más tempranos de la enfermedad, que favorezcan el pronóstico y que sean de ayuda para la investigación en biotecnología diagnóstica y terapia médica.

Biografía del autor

Peter Stain Vargas Manrique, Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia
Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina; Medico general. Tunja - Boyacá, Colombia
Jonathan Alexander Siabato Barrios, Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia.
Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina; médico interno, Tunja - Boyacá, Colombia.
Juan Sebastián Castro Guerrero, Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia.
Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina; médico interno, Tunja - Boyacá, Colombia.
Carlos Ernesto Morales, Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina, Tunja - Boyacá, Colombia.
Universidad Pedagógica y Tecnológica de Colombia, Escuela de Medicina; médico interno, Tunja - Boyacá, Colombia.

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2022-04-22
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